Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 13/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7068369 | 0.76 | RAPGEF4 (0.48) | RAPGEF4LCK | |
| SCHEMBL13064955 | 0.74 | CDK5 (0.61) | CDK1CCNB1CCNA2CCNE1CDK2 | |
| SCHEMBL1183435 | 0.74 | RAPGEF4 (0.45) | RAPGEF4 | |
| SCHEMBL29941689 | 0.73 | LCK (0.49) | RAPGEF4LCKCDK5KDRLMNA | |
| SCHEMBL31247573 | 0.73 | KDM4E (0.57) | LCKCDK1CCNB1CCNA2CCNE1 | |
| SCHEMBL14614677 | 0.73 | MKNK2 (0.43) | CDK1CCNB1CCNA2CCNE1CDK2 | |
| SCHEMBL14954692 | 0.72 | RAPGEF4 (0.52) | RAPGEF4LCKCDK5KDRLMNA | |
| SCHEMBL29741837 | 0.71 | — | — | |
| SCHEMBL1911881 | 0.71 | — | — | |
| SCHEMBL10303879 | 0.71 | RAPGEF4 (0.64) | RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149583-A2 | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues | Pfizer Products Inc. (US) | 2001-10-31 | — | — | EP | claimed |