Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.58 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.55 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 4/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744827 | 0.94 | LTA4H (0.60) | LTA4HPSMB1PSMB5PSMB2PTPN1 | |
| Hydrochloric Acid SCHEMBL6749948 | 0.93 | LTA4H (0.58) | LTA4HPSMB1PSMB5PSMB2PTPN1 | |
| Hydrochloric Acid SCHEMBL6746982 | 0.93 | ESR1 (0.59) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL6748810 | 0.84 | ESR1 (0.63) | PTPN1ESR1ESR2 | |
| SCHEMBL6748780 | 0.84 | LTA4H (0.56) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL6744378 | 0.84 | ESR1 (0.58) | LTA4HPTPN1ESR1ESR2 | |
| SCHEMBL6745462 | 0.83 | ESR1 (0.61) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| Hydrochloric Acid SCHEMBL6749894 | 0.83 | ESR1 (0.59) | LTA4HPTPN1ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL6745263 | 0.83 | LTA4H (0.55) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| Hydrochloric Acid SCHEMBL6751611 | 0.83 | ESR1 (0.66) | PTPN1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265575-B1 | THROMBIN INHIBITORS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| US-6251921-B1 | ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6025382-A | Antithrombotic diamines | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| EP-0863755-A4 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0863755-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997025033-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |