Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.48 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.45 |
| ▸ | NOS2 | P35228 | 4/20 | 0.43 |
| ▸ | NOS3 | P29474 | 3/20 | 0.43 |
| ▸ | NOS1 | P29475 | 3/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | NPY4R | P50391 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL7432633 | 1.00 | OTC (0.48) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL29664038 | 1.00 | OTC (0.48) | OTCDDAH1NOS2NOS3NOS1 | |
| Trifluoroacetic Acid SCHEMBL31651399 | 0.91 | NPY4R (0.40) | OTCDDAH1NPY4RS1PR1S1PR3 | |
| Arginine SCHEMBL1790 | 0.90 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL6374054 | 0.90 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL288132 | 0.90 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL31663499 | 0.90 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL7928810 | 0.90 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL2411547 | 0.90 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL1791 | 0.90 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0577775-A4 | ANTI-THROMBOTIC PEPTIDES AND PSEUDOPEPTIDES. | RHONE POULENC RORER INT (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0577775-A1 | ANTI-THROMBOTIC PEPTIDES AND PSEUDOPEPTIDES | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1994-01-12 | — | — | EP | disclosed |
| WO-1992017196-A1 | ANTI-THROMBOTIC PEPTIDES AND PSEUDOPEPTIDES | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-10-15 | — | — | WO | disclosed |