Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64763 | 0.87 | MAPK1 (0.67) | MAPK1KDM4EL3MBTL1HDAC1HDAC6 | |
| SCHEMBL30574349 | 0.87 | MAPK1 (0.67) | MAPK1KDM4EL3MBTL1HDAC1HDAC6 | |
| SCHEMBL7362601 | 0.84 | MAPK1 (0.51) | MAPK1KDM4EL3MBTL1HDAC1HDAC6 | |
| SCHEMBL31029130 | 0.83 | AR (0.52) | MAPK1L3MBTL1HDAC1HDAC6CYP4A11 | |
| SCHEMBL7528438 | 0.81 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1HDAC1HDAC6 | |
| SCHEMBL132853 | 0.80 | — | — | |
| SCHEMBL29450844 | 0.80 | — | — | |
| SCHEMBL27625609 | 0.80 | MAPK1 (0.57) | MAPK1KDM4EL3MBTL1HDAC1HDAC6 | |
| Ethyl Acetate SCHEMBL575043 | 0.79 | MAPK1 (0.53) | MAPK1KDM4EL3MBTL1HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL6441917 | 0.78 | TSHR (0.46) | KDM4EHDAC1HDAC6ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0631580-A1 | PYRIDO 2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-01-04 | — | — | EP | disclosed |
| WO-1993019068-A1 | PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-09-30 | — | — | WO | disclosed |