Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 2/20 | 0.47 |
| ▸ | GABRD | O14764 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.47 |
| ▸ | GABRE | P78334 | 2/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532 | 0.87 | MAPK1 (0.65) | MAPK1KDM4EL3MBTL1LOXL2GABRP | |
| SCHEMBL29826707 | 0.87 | MAPK1 (0.65) | MAPK1KDM4EL3MBTL1LOXL2GABRP | |
| Hydrochloric Acid SCHEMBL2177614 | 0.86 | MAPK1 (0.62) | MAPK1KDM4EL3MBTL1LOXL2GABRP | |
| SCHEMBL7443540 | 0.84 | MAPK1 (0.53) | MAPK1KDM4EL3MBTL1LOXL2HDAC1 | |
| SCHEMBL642783 | 0.79 | — | — | |
| SCHEMBL30811769 | 0.79 | — | — | |
| SCHEMBL25305229 | 0.77 | RAB9A (0.60) | MAPK1L3MBTL1LOXL2SMN1; SMN2TP53 | |
| Tetrahydrofuran SCHEMBL28037003 | 0.77 | MAPK1 (0.51) | MAPK1KDM4EL3MBTL1GABRPGABRD | |
| SCHEMBL12970275 | 0.77 | SMN1; SMN2 (0.55) | MAPK1KDM4EL3MBTL1LOXL2SMN1; SMN2 | |
| SCHEMBL11125851 | 0.77 | SMN1; SMN2 (0.61) | KDM4ELOXL2SMN1; SMN2TP53CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007141-A1 | HETEROCYCLIC 3-PHENYLPYRROLIDIN-2-ONES, THEIR PREPARATION AND USE FOR THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING TUMOR NECROSIS FACTOR PRODUCTION | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-15 | — | — | WO | disclosed |