Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438391 | 0.89 | CDK2 (0.40) | KDM4EALDH1A1MAPTRAB9AGSK3B | |
| SCHEMBL7438974 | 0.82 | CHEK1 (0.33) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7436122 | 0.81 | KDM4E (0.38) | KDM4EALDH1A1MAPTRAB9AGSK3B | |
| SCHEMBL13304696 | 0.78 | KDM4E (0.36) | KDM4EALDH1A1MAPTRAB9AGSK3B | |
| SCHEMBL12953210 | 0.78 | GSK3B (0.52) | KDM4EALDH1A1MAPTRAB9AGSK3B | |
| SCHEMBL13304689 | 0.76 | MAPT (0.35) | KDM4EALDH1A1MAPTRAB9ACDK2 | |
| SCHEMBL12953799 | 0.76 | GSK3B (0.42) | KDM4EALDH1A1MAPTRAB9AGSK3B | |
| SCHEMBL5119212 | 0.74 | PDE10A (0.40) | KDM4EALDH1A1MAPTRAB9AGSK3B | |
| SCHEMBL7447843 | 0.72 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPTRAB9AGSK3B | |
| SCHEMBL5926222 | 0.72 | CDK2 (0.41) | KDM4EALDH1A1MAPTRAB9AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |