Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274102 | 0.86 | MAPT (0.51) | LMNASMN1; SMN2MAPK1PPARGPPARA | |
| SCHEMBL7272682 | 0.86 | MAPT (0.54) | PPARGPPARAMAPTTDP1KDM4E | |
| SCHEMBL7294844 | 0.85 | MAPT (0.50) | LMNASMN1; SMN2MAPK1PPARGPPARA | |
| SCHEMBL7287001 | 0.84 | MAPT (0.47) | LMNASMN1; SMN2MAPK1PPARGPPARA | |
| SCHEMBL7288018 | 0.84 | SLC2A1 (0.53) | SMN1; SMN2APEX1MAPTTDP1MEN1 | |
| SCHEMBL7284175 | 0.83 | APEX1 (0.53) | SMN1; SMN2APEX1MAPTTDP1MEN1 | |
| SCHEMBL10397460 | 0.81 | PPARG (0.56) | LMNASMN1; SMN2MAPK1PPARGPPARA | |
| SCHEMBL7274826 | 0.78 | MAPT (0.55) | LMNASMN1; SMN2MAPK1PPARGPPARA | |
| SCHEMBL7439149 | 0.78 | FABP4 (0.47) | SMN1; SMN2APEX1MAPTTDP1MEN1 | |
| SCHEMBL9516862 | 0.77 | MEN1 (0.48) | LMNASMN1; SMN2MAPK1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292202-B1 | 2-(3,4-DIHYDROXYPHENYL ETHYL AMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL COMPOUNDS | FISONS plc (GB) | 1992-09-02 | — | — | EP | disclosed |
| US-4939147-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC. (GB) | 1990-07-03 | — | — | US | disclosed |
| US-4922022-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC (GB) | 1990-05-01 | — | — | US | disclosed |
| EP-0314725-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS plc (GB) | 1989-05-10 | — | — | EP | disclosed |
| WO-1988009326-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS PLC (GB) | 1988-12-01 | — | — | WO | disclosed |
| EP-0292202-A1 | 2-(3,4-Dihydroxyphenyl ethyl amines, their preparation and use as pharmaceutical compounds | FISONS plc (GB) | 1988-11-23 | — | — | EP | disclosed |