Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.48 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441455 | 0.82 | PDE4A (0.66) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7446386 | 0.82 | PDE4A (0.69) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7442481 | 0.82 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| Hydrochloric Acid SCHEMBL7433162 | 0.82 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7441893 | 0.82 | PDE4A (0.74) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7450694 | 0.82 | PDE4A (0.74) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7449137 | 0.80 | PDE4A (0.66) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7435677 | 0.80 | PDE4A (0.85) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7439484 | 0.80 | PDE4A (0.71) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| Hydrochloric Acid SCHEMBL7438842 | 0.80 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4CTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |