Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7438842 | 0.99 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL8544271 | 0.85 | PDE4A (0.61) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7440005 | 0.85 | PDE4A (0.69) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| Hydrochloric Acid SCHEMBL7440541 | 0.84 | PDE4A (0.67) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7441893 | 0.82 | PDE4A (0.74) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7450694 | 0.82 | PDE4A (0.74) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7437841 | 0.82 | PDE4A (0.58) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7441455 | 0.81 | PDE4A (0.66) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7446386 | 0.81 | PDE4A (0.69) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7435677 | 0.81 | PDE4A (0.85) | PDE4APDE4BPDE4DPDE4CTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |