Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.55 |
| ▸ | TOP1 | P11387 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27424554 | 0.88 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL5257263 | 0.86 | CYP2C9 (0.73) | PDE4APDE4BPDE4DPDE4CCYP2C9 | |
| SCHEMBL7438217 | 0.84 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7445324 | 0.82 | PDE4D (0.71) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7441260 | 0.81 | PDE4A (0.61) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7450694 | 0.81 | PDE4A (0.74) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| Hydrochloric Acid SCHEMBL9130372 | 0.80 | PDE4A (0.60) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7433402 | 0.80 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7439484 | 0.79 | PDE4A (0.71) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7441849 | 0.79 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4CTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |