Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.71 |
| ▸ | PDE4A | P27815 | 8/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.61 |
| ▸ | TOP1 | P11387 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438217 | 0.85 | PDE4A (0.65) | PDE4DPDE4APDE4BPDE4CTOP1 | |
| SCHEMBL7433402 | 0.83 | PDE4A (0.65) | PDE4DPDE4APDE4BPDE4CTOP1 | |
| SCHEMBL7441260 | 0.82 | PDE4A (0.61) | PDE4DPDE4APDE4BPDE4CTOP1 | |
| SCHEMBL7441893 | 0.82 | PDE4A (0.74) | PDE4DPDE4APDE4BPDE4CTOP1 | |
| SCHEMBL7443605 | 0.82 | PDE4A (0.61) | PDE4DPDE4APDE4BPDE4CTOP1 | |
| SCHEMBL7450694 | 0.82 | PDE4A (0.74) | PDE4DPDE4APDE4BPDE4CTOP1 | |
| SCHEMBL7437116 | 0.82 | PDE4A (0.70) | PDE4DPDE4APDE4BPDE4CTOP1 | |
| Hydrochloric Acid SCHEMBL9130372 | 0.81 | PDE4A (0.60) | PDE4DPDE4APDE4BPDE4CTOP1 | |
| SCHEMBL23293733 | 0.81 | MAP4K4 (0.59) | PDE4DPDE4APDE4BPDE4CTOP1 | |
| SCHEMBL27652747 | 0.81 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |