Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7436727 | 0.99 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CCYP2C9 | |
| SCHEMBL9129273 | 0.86 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4CCYP2C9 | |
| SCHEMBL7441262 | 0.86 | CCR3 (0.44) | PDE4APDE4DPDE4BPDE4CCYP2C9 | |
| SCHEMBL7437304 | 0.85 | PDE4A (0.41) | PDE4APDE4DPDE4BPDE4CCCR3 | |
| SCHEMBL7441455 | 0.81 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7450047 | 0.81 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7433162 | 0.81 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7442481 | 0.81 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7450702 | 0.80 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7436994 | 0.80 | PDE4A (0.63) | PDE4APDE4DPDE4BPDE4CADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |