Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443607 | 0.86 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| Hydrochloric Acid SCHEMBL7436727 | 0.85 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7441455 | 0.81 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7441262 | 0.81 | CCR3 (0.44) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7450047 | 0.81 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Hydrochloric Acid SCHEMBL7433162 | 0.81 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7442481 | 0.81 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7437304 | 0.79 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL7446386 | 0.76 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7439698 | 0.75 | ITK (0.43) | KDM4EMEN1ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |