Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | EED | O75530 | 1/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18618447 | 0.82 | HTR2C (0.59) | HTR2CHTR2AHTR2BEEDSLC9A1 | |
| SCHEMBL16874548 | 0.82 | REN (0.52) | HTR2C | |
| SCHEMBL16874609 | 0.82 | REN (0.52) | HTR2C | |
| SCHEMBL16874612 | 0.82 | REN (0.52) | HTR2C | |
| SCHEMBL17474525 | 0.81 | HTR2C (0.55) | HTR2CHTR2AHTR2BSLC9A1HTR6 | |
| SCHEMBL7840122 | 0.81 | HTR2C (0.57) | HTR2CHTR2AHTR2BHTR6 | |
| Hydrochloric Acid SCHEMBL7842128 | 0.79 | HTR2C (0.58) | HTR2CHTR2AHTR2BHTR6 | |
| Hydrochloric Acid SCHEMBL7842131 | 0.79 | HTR2C (0.58) | HTR2CHTR2AHTR2BHTR6 | |
| SCHEMBL765244 | 0.79 | HTR2C (0.51) | HTR2CHTR2AHTR2BSLC9A1DDB1 | |
| SCHEMBL8032211 | 0.79 | HTR2C (0.82) | HTR2CHTR2AHTR2BEEDHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |