Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440186 | 0.93 | AGTR1 (0.36) | AGTR1AGTR2KDM4EMEN1MAPT | |
| SCHEMBL7448995 | 0.91 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL7432327 | 0.86 | AGTR1 (0.36) | AGTR1AGTR2CMKLR1 | |
| SCHEMBL7438075 | 0.84 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL7438693 | 0.84 | AGTR1 (0.35) | AGTR1AGTR2CXCR4CMKLR1 | |
| SCHEMBL7435724 | 0.84 | AGTR1 (0.36) | AGTR1AGTR2KDM4EMAPTALDH1A1 | |
| SCHEMBL7440056 | 0.84 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL7432972 | 0.82 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL7432985 | 0.81 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL7434028 | 0.81 | AGTR1 (0.34) | AGTR1AGTR2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |