Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 8/20 | 0.49 |
| ▸ | NOS2 | P35228 | 8/20 | 0.49 |
| ▸ | NOS3 | P29474 | 5/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27547771 | 1.00 | OTC (0.50) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL27890320 | 0.98 | OTC (0.49) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL27799680 | 0.95 | OTC (0.51) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL15902175 | 0.93 | OTC (0.50) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL6148909 | 0.93 | OTC (0.50) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL1527718 | 0.93 | OTC (0.50) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL27797253 | 0.93 | OTC (0.53) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL28280254 | 0.93 | OTC (0.53) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL7928810 | 0.93 | OTC (0.56) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL1791 | 0.93 | OTC (0.56) | OTCNOS1NOS2NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118184547-A | Method for recycling and preparing arginine from waste water of tetrodotoxin extracted and separated from puffer fish viscera | 中洋生物科技(上海)股份有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-101486644-A | Preparation of arginine acetylsalicylate | UNIV HEFEI TECHNOLOGY (CN) | 2009-07-22 | — | — | CN | claimed |
| CN-118184547-A | Method for recycling and preparing arginine from waste water of tetrodotoxin extracted and separated from puffer fish viscera | 中洋生物科技(上海)股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-118184547-A | Method for recycling and preparing arginine from waste water of tetrodotoxin extracted and separated from puffer fish viscera | 中洋生物科技(上海)股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-102282159-B | Peptide derivant and using binding substances form as the application of molecular vehicle | VECT-HORUS (FR) | 2015-11-25 | — | — | CN | disclosed |
| CN-102282159-A | Peptide derivatives and use thereof as carriers for molecules in the form of conjugates | — | 2011-12-14 | — | — | CN | disclosed |
| CN-101704766-A | Preparation method of arginine aspirin and powder-injection of arginine aspirin | ANHUI BBCA PHARMACEUTICAL CO L | 2010-05-12 | — | — | CN | disclosed |
| CN-101486644-A | Preparation of arginine acetylsalicylate | UNIV HEFEI TECHNOLOGY (CN) | 2009-07-22 | — | — | CN | disclosed |
| CN-1281737-C | Producing basic proteinase by vibrio metschnikovii DL 33-51 strain | OCEAN UNIV CHINA (CN) | 2006-10-25 | — | — | CN | disclosed |
| EP-0748333-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1999036506-A1 | MICROORGANISMS AND PREPARATION FOR DISPOSING OF ORGANIC WASTEWATER | CHEIL JEDANG CORPORATION (KR) | 1999-07-22 | — | — | WO | disclosed |
| EP-0670310-B1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | LILLY CO ELI (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5602101-A | THROMBIN INHIBITORS, ANTICOAGULANTS | ELI LILLY AND COMPANY (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0748333-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1996-12-18 | — | — | EP | disclosed |
| WO-1995023809-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1995-09-08 | — | — | WO | disclosed |
| EP-0670310-A1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | ELI LILLY AND COMPANY (US) | 1995-09-06 | — | — | EP | disclosed |