Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 5/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 10/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 7/20 | 0.39 |
| ▸ | CASP7 | P55210 | 4/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444637 | 0.99 | CASP1 (0.48) | CASP1HRH1CASP3CASP8CASP7 | |
| Hydrochloric Acid SCHEMBL7440303 | 0.99 | CASP1 (0.48) | CASP1HRH1CASP3CASP8CASP7 | |
| Hydrochloric Acid SCHEMBL7442485 | 0.98 | CASP1 (0.47) | CASP1HRH1CASP3CASP8CASP7 | |
| SCHEMBL7427023 | 0.91 | CASP1 (0.41) | CASP1HRH1CASP3 | |
| SCHEMBL7436591 | 0.90 | CASP1 (0.41) | CASP1HRH1CASP3APAF1MAPT | |
| SCHEMBL7440398 | 0.87 | CASP1 (0.52) | CASP1HRH1CASP3CASP8CASP7 | |
| SCHEMBL8173169 | 0.85 | CASP1 (0.50) | CASP1HRH1CASP3CASP8CASP7 | |
| SCHEMBL7677924 | 0.84 | CASP1 (0.55) | CASP1HRH1CASP3CASP8CASP7 | |
| SCHEMBL7436111 | 0.84 | CASP1 (0.49) | CASP1HRH1CASP3CASP8CASP7 | |
| SCHEMBL7436395 | 0.84 | USP2 (0.49) | CASP1HRH1CASP3CASP8CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | claimed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | claimed |