Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195404 | 0.78 | FGFR1 (0.65) | HPGDFGFR1ALDH1A1NPC1GLA | |
| SCHEMBL8194971 | 0.78 | FGFR1 (0.65) | HPGDFGFR1ALDH1A1NPC1GLA | |
| Hydrochloric Acid SCHEMBL8194663 | 0.77 | FGFR1 (0.63) | HPGDFGFR1ALDH1A1NPC1GLA | |
| SCHEMBL7505408 | 0.76 | CYP11B1 (0.61) | HPGDFGFR1ALDH1A1GABRPGABRD | |
| SCHEMBL7449598 | 0.76 | HPGD (0.84) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL178443 | 0.75 | NCF1 (0.66) | HPGDALDH1A1SMN1; SMN2NCF1NOS1 | |
| SCHEMBL6801520 | 0.75 | CNR1 (0.46) | HPGDFGFR1SRCALDH1A1NPC1 | |
| SCHEMBL17678347 | 0.72 | KDM4E (0.51) | HPGDFGFR1SRCALDH1A1SMN1; SMN2 | |
| SCHEMBL7986978 | 0.72 | FGFR1 (1.00) | FGFR1SRCKDR | |
| SCHEMBL4504294 | 0.72 | FGFR1 (0.45) | HPGDFGFR1SRCKDRGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071909-A | Phenylbenzimidazole derivatives as ligands for GABA receptors | MERCK SHARPE & DOHME LTD. (GB) | 2000-06-06 | — | — | US | claimed |
| EP-0968191-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-01-05 | — | — | EP | claimed |
| WO-1998034923-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1998-08-13 | — | — | WO | claimed |
| US-6071909-A | Phenylbenzimidazole derivatives as ligands for GABA receptors | MERCK SHARPE & DOHME LTD. (GB) | 2000-06-06 | — | — | US | disclosed |