Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 12/20 | 0.39 |
| ▸ | PLG | P00747 | 3/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | PLAT | P00750 | 3/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434470 | 0.92 | PLAU (0.44) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL6434219 | 0.84 | PLAU (0.52) | PLAUPLGPLATALDH1A1 | |
| Hydrochloric Acid SCHEMBL7588121 | 0.84 | PLAU (0.48) | PLAUPLGPLATBCL2L1MCL1 | |
| SCHEMBL6432627 | 0.84 | PLAU (0.56) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL6437213 | 0.84 | PLAU (0.46) | PLAUMMP3ALDH1A1 | |
| SCHEMBL6437555 | 0.83 | PLAU (0.47) | PLAUPLGPLATALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL6438528 | 0.83 | PLAU (0.46) | PLAUMMP3ALDH1A1 | |
| SCHEMBL6434318 | 0.83 | PLAU (0.57) | PLAUPLGMMP3PLAT | |
| Hydrochloric Acid SCHEMBL7449769 | 0.82 | PLAU (0.44) | PLAUBCL2L1MCL1ALDH1A1KDM4E | |
| SCHEMBL6434326 | 0.82 | PLAU (0.56) | PLAUPLGMMP3PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |