Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ADH5 | P11766 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444948 | 1.00 | KMT2A (0.44) | KMT2ARARBFFAR4MAPTHTT | |
| SCHEMBL7440277 | 0.90 | ALDH1A1 (0.43) | KMT2ARARBALDH1A1HPGDS1PR1 | |
| SCHEMBL7440265 | 0.90 | ALDH1A1 (0.43) | KMT2ARARBALDH1A1HPGDS1PR1 | |
| SCHEMBL7433362 | 0.88 | APP (0.44) | KMT2ARARBALDH1A1HPGDS1PR1 | |
| SCHEMBL7433367 | 0.88 | APP (0.44) | KMT2ARARBALDH1A1HPGDS1PR1 | |
| SCHEMBL7446294 | 0.88 | S1PR1 (0.44) | KMT2ARARBMAPTSMN1; SMN2FFAR1 | |
| SCHEMBL7446292 | 0.88 | S1PR1 (0.44) | KMT2ARARBMAPTSMN1; SMN2FFAR1 | |
| SCHEMBL7443647 | 0.87 | MCHR1 (0.42) | RARBADH5 | |
| SCHEMBL7448419 | 0.87 | ALDH1A1 (0.47) | KMT2ARARBMAPTHTTSMN1; SMN2 | |
| SCHEMBL7437491 | 0.87 | MCHR1 (0.42) | RARBADH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169103-B1 | FOR TREATMENT OF ATHEROSCLEROTIC PLAQUE RUPTURE, AORTIC ANEURISM, HEART FAILURE, ULCERS, CANCER, INFLAMMATION, PAIN, ARTHRITIS, OSTEOPOROSIS, AND OTHER AUTOIMMUNE OR INFLAMMATORY DISORDERS DEPENDENT UPON TISSUE INVASION BY LEUKOCYTES | WARNER-LAMBERT | 2001-01-02 | — | — | US | claimed |
| US-6265432-B1 | CARDIOVASCULAR DISORDERS; ANTIINFLAMMATORY AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT | 2001-07-24 | — | — | US | disclosed |
| US-6169103-B1 | FOR TREATMENT OF ATHEROSCLEROTIC PLAQUE RUPTURE, AORTIC ANEURISM, HEART FAILURE, ULCERS, CANCER, INFLAMMATION, PAIN, ARTHRITIS, OSTEOPOROSIS, AND OTHER AUTOIMMUNE OR INFLAMMATORY DISORDERS DEPENDENT UPON TISSUE INVASION BY LEUKOCYTES | WARNER-LAMBERT | 2001-01-02 | — | — | US | disclosed |