Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442855 | 0.77 | KDM4E (0.60) | MAPTKDM4ECYP3A4IDO1LMNA | |
| SCHEMBL10355251 | 0.75 | CYP3A4 (0.58) | MAPTKDM4ECYP3A4IDO1MAPK14 | |
| Hydrochloric Acid SCHEMBL7430812 | 0.75 | CYP3A4 (0.58) | MAPTKDM4ECYP3A4IDO1LMNA | |
| Hydrochloric Acid SCHEMBL10355391 | 0.75 | KDM4E (0.58) | MAPTKDM4ECYP3A4IDO1MAPK14 | |
| Bromide SCHEMBL10355410 | 0.75 | CYP3A4 (0.58) | MAPTKDM4ECYP3A4IDO1MAPK14 | |
| SCHEMBL1502457 | 0.75 | CYP3A4 (0.58) | MAPTKDM4ECYP3A4IDO1MAPK14 | |
| SCHEMBL1501875 | 0.74 | KDM4E (0.56) | MAPTKDM4ECYP3A4IDO1LMNA | |
| Hydrochloric Acid SCHEMBL10355418 | 0.74 | KDM4E (0.56) | MAPTKDM4ECYP3A4IDO1MAPK14 | |
| SCHEMBL28131043 | 0.73 | KDM4E (0.55) | MAPTKDM4ECYP3A4IDO1KMT2A | |
| SCHEMBL11742762 | 0.72 | LMNA (0.45) | MAPTKDM4ECYP3A4LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397365-B1 | Arylthiazolylimidazoles as 5HT3 Antagonists | PFIZER (US) | 1994-03-02 | — | — | EP | disclosed |
| EP-0397365-A1 | Arylthiazolylimidazoles as 5HT3 Antagonists | PFIZER INC. (US) | 1990-11-14 | — | — | EP | disclosed |
| US-4914207-A | ANTIEMETICS | PFIZER INC. (US) | 1990-04-03 | — | — | US | disclosed |