Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GGPS1 | O95749 | 6/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.39 |
| ▸ | FDPS | P14324 | 9/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9576868 | 1.00 | TSHR (0.44) | TSHRTHRBGGPS1SMPD1FDPS | |
| SCHEMBL297925 | 0.97 | TSHR (0.39) | TSHRTHRBGGPS1SMPD1FDPS | |
| SCHEMBL9625652 | 0.94 | TSHR (0.37) | TSHRTHRBGGPS1SMPD1FDPS | |
| SCHEMBL23152664 | 0.93 | TSHR (0.38) | TSHRTHRBGGPS1SMPD1FDPS | |
| SCHEMBL3677688 | 0.93 | TSHR (0.38) | TSHRTHRBGGPS1SMPD1FDPS | |
| SCHEMBL8056144 | 0.93 | TSHR (0.38) | TSHRTHRBGGPS1SMPD1FDPS | |
| SCHEMBL8901964 | 0.90 | TSHR (0.40) | TSHRTHRBGGPS1SMPD1FDPS | |
| SCHEMBL9850241 | 0.90 | TSHR (0.38) | TSHRTHRBGGPS1SMPD1FDPS | |
| SCHEMBL9625864 | 0.90 | TSHR (0.33) | TSHRTHRBGGPS1SMPD1FDPS | |
| SCHEMBL8039291 | 0.88 | TSHR (0.35) | TSHRTHRBFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721459-B1 | NOVEL OLIGOSACCHARIDE-CONTAINING 14-AMINOSTEROID COMPOUNDS AND NOVEL DIASTEREOSELECTIVE AMINOSTEROID PROCESS CHEMISTRY | PROCTER & GAMBLE (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5849889-A | Oligosaccharide-containing 14 aminosteroid compounds and novel diastereoselective aminosteroid process chemistry | THE PROCTER & GAMBLE COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0863149-A1 | Process for introducing an amino group on the 14-position of a steroid nucleus | THE PROCTER & GAMBLE COMPANY (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5710259-A | TREATING CONGESTIVE HEART FAILURE | THE PROCTER & GAMBLE COMPANY (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0721459-A1 | NOVEL OLIGOSACCHARIDE-CONTAINING 14-AMINOSTEROID COMPOUNDS AND NOVEL DIASTEREOSELECTIVE AMINOSTEROID PROCESS CHEMISTRY | THE PROCTER & GAMBLE COMPANY (US) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995008557-A1 | NOVEL OLIGOSACCHARIDE-CONTAINING 14-AMINOSTEROID COMPOUNDS AND NOVEL DIASTEREOSELECTIVE AMINOSTEROID PROCESS CHEMISTRY | THE PROCTER & GAMBLE COMPANY (US) | 1995-03-30 | — | — | WO | disclosed |