Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 14/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379973 | 1.00 | DRD1 (0.58) | DRD1ADRA2AADRA2BADRA2CADRA1D | |
| Bromide SCHEMBL7320921 | 0.99 | DRD1 (0.57) | DRD1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7444013 | 0.88 | DRD1 (0.55) | DRD1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL10380332 | 0.88 | DRD1 (0.55) | DRD1ADRA2AADRA2BADRA2CADRA1D | |
| Bromide SCHEMBL7312469 | 0.87 | DRD1 (0.54) | DRD1ADRA2AADRA2BADRA2CADRA1D | |
| Bromide SCHEMBL7446051 | 0.87 | DRD1 (0.54) | DRD1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL27404639 | 0.81 | ADRA2A (0.51) | DRD1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9802420 | 0.76 | DRD1 (0.41) | DRD1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9037954 | 0.73 | DRD1 (1.00) | DRD1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL10380152 | 0.73 | DRD1 (1.00) | DRD1ADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474767-B1 | DOPAMINE AGONISTS | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | claimed |
| EP-0474767-A4 | DOPAMINE AGONISTS | — | 1992-07-08 | — | — | EP | claimed |
| EP-0474767-A1 | DOPAMINE AGONISTS. | ABBOTT LAB (US) | 1992-03-18 | — | — | EP | claimed |
| WO-1996038435-A1 | DOPAMINE AGONISTS | ABBOTT LABORATORIES (US) | 1996-12-05 | — | — | WO | disclosed |
| EP-0474767-B1 | DOPAMINE AGONISTS | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | disclosed |