Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 8/20 | 0.64 |
| ▸ | HTR1B | P28222 | 7/20 | 0.64 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445563 | 0.85 | HTR1D (0.56) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL8886408 | 0.78 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL7434651 | 0.78 | HTR1D (0.83) | HTR1DHTR1BDRD2DRD1 | |
| SCHEMBL7437054 | 0.78 | HTR1D (0.60) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL7441409 | 0.73 | HTR1D (0.57) | HTR1DHTR1BHTR1A | |
| SCHEMBL9451722 | 0.73 | DRD2 (0.71) | DRD2DRD3DRD4DRD1HTR1A | |
| SCHEMBL10985541 | 0.72 | HTR1D (0.66) | HTR1DHTR1BDRD3HTR1A | |
| SCHEMBL8315482 | 0.72 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL7437400 | 0.71 | FYN (0.43) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL8126165 | 0.71 | HTR1D (0.64) | HTR1DHTR1BDRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |