Tyrosine

Tyrosine

SCHEMBL7445681

NC(Cc1ccc(O)cc1)C(=O)O.O=C(O)C(F)(F)F

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.83
GRB2 P62993 1/20 0.69
PTPN1 P18031 2/20 0.63
PTGS1 P23219 3/20 0.59
ALPI P09923 1/20 0.59
PKM P14618 1/20 0.59
XIAP P98170 1/20 0.59
ALOX15 P16050 3/20 0.56
HIF1A Q16665 3/20 0.56
KDM4E B2RXH2 2/20 0.56
TDP1 Q9NUW8 2/20 0.56
USP2 O75604 1/20 0.56
EGFR P00533 1/20 0.56
LCK P06239 1/20 0.56
FYN P06241 1/20 0.56
ADORA3 P0DMS8 1/20 0.56
HTR2A P28223 1/20 0.56
PTGS2 P35354 1/20 0.56
RECQL P46063 1/20 0.56
HSD17B10 Q99714 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL29664050 1.00 SLC7A5 (0.83) SLC7A5GRB2PTPN1PTGS1ALPI
Tyrosine SCHEMBL11520041 0.91 SLC7A5 (1.00) SLC7A5GRB2PTGS1ALPIPKM
Tyrosine SCHEMBL11520027 0.91 SLC7A5 (1.00) SLC7A5GRB2PTGS1ALPIPKM
Tyrosine SCHEMBL10978805 0.91 SLC7A5 (1.00) SLC7A5GRB2PTGS1ALPIPKM
Tyrosine SCHEMBL11676395 0.91 SLC7A5 (1.00) SLC7A5GRB2PTGS1ALPIPKM
Tyrosine SCHEMBL638520 0.91 SLC7A5 (1.00) SLC7A5GRB2PTGS1ALPIPKM
Tyrosine SCHEMBL11676367 0.91 SLC7A5 (1.00) SLC7A5GRB2PTGS1ALPIPKM
Tyrosine SCHEMBL1581 0.91 SLC7A5 (1.00) SLC7A5GRB2PTGS1ALPIPKM
Tyrosine SCHEMBL1580 0.91 SLC7A5 (1.00) SLC7A5GRB2PTGS1ALPIPKM
Tyrosine SCHEMBL10978820 0.91 SLC7A5 (1.00) SLC7A5GRB2PTGS1ALPIPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0577775-A4 ANTI-THROMBOTIC PEPTIDES AND PSEUDOPEPTIDES. RHONE POULENC RORER INT (US) 1995-01-11 EP disclosed
EP-0577775-A1 ANTI-THROMBOTIC PEPTIDES AND PSEUDOPEPTIDES RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1994-01-12 EP disclosed
WO-1992017196-A1 ANTI-THROMBOTIC PEPTIDES AND PSEUDOPEPTIDES RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1992-10-15 WO disclosed