Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 9/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 2/20 | 0.35 |
| ▸ | SKP1 | P63208 | 2/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442154 | 0.75 | CYP2C9 (0.43) | — | |
| SCHEMBL19379801 | 0.65 | CYP11B2 (0.47) | ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL1706174 | 0.65 | MAPK1 (0.55) | ALDH1A1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL1706172 | 0.65 | MAPK1 (0.55) | ALDH1A1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL12535753 | 0.65 | MAPK1 (0.55) | ALDH1A1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL1669097 | 0.64 | HTT (0.55) | ALDH1A1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL7352660 | 0.64 | MAPK1 (0.54) | ALDH1A1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL13994325 | 0.63 | MAPK1 (0.51) | ALDH1A1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL17708312 | 0.63 | HTT (0.54) | ALDH1A1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL4546718 | 0.63 | HTT (0.54) | ALDH1A1LMNAMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058690-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES | APOTEX INC. (CA) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999045027-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES | APOTEX INC. (CA) | 1999-09-10 | — | — | WO | disclosed |