Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 12/20 | 0.60 |
| ▸ | CTRC | Q99895 | 2/20 | 0.51 |
| ▸ | F10 | P00742 | 2/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442091 | 0.89 | F2 (0.66) | F2CTRCF10PRSS2 | |
| SCHEMBL7451365 | 0.87 | F2 (0.67) | F2CTRCF10PRSS2SLC6A2 | |
| SCHEMBL8696239 | 0.81 | IKBKB (0.43) | F2CTRCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7603459 | 0.77 | F2 (0.62) | F2CTRCF10PRSS2 | |
| SCHEMBL7449783 | 0.76 | F2 (0.82) | F2CTRCF10PRSS2EED | |
| SCHEMBL6553019 | 0.76 | F2 (0.73) | F2CTRCF10PRSS2 | |
| SCHEMBL7601994 | 0.76 | F2 (0.71) | F2CTRCF10PRSS2 | |
| SCHEMBL7447411 | 0.75 | F2 (1.00) | F2CTRCF10PRSS2 | |
| SCHEMBL13107014 | 0.75 | EED (0.67) | SLC6A2SLC6A4SLC6A3MAP2K1EED | |
| SCHEMBL7451490 | 0.74 | F2 (0.70) | F2CTRCF10PRSS2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859607-B1 | GUANIDINO PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-0859607-A4 | GUANIDINO PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0859607-A1 | GUANIDINO PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1998-08-26 | — | — | EP | disclosed |
| US-5792769-A | POTENT ANTICOAGULANT, ANTIINFLAMMATORY AGENT; TREATMENT/PROPHYLAXIS OF RESPIRATORY SYSTEM DISORDERS, VASCULAR SYSTEM DISORDERS, ANTITUMOR AGENTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1997011693-A1 | GUANIDINO PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1997-04-03 | — | — | WO | disclosed |