Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440398 | 0.93 | CASP1 (0.52) | TP53CASP1CASP3PKMHTT | |
| SCHEMBL7436395 | 0.91 | USP2 (0.49) | TP53CASP1CASP3PKMHTT | |
| SCHEMBL7438171 | 0.90 | CASP1 (0.48) | TP53CASP1MAPTALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL7434212 | 0.90 | USP2 (0.49) | TP53CASP1CASP3PKMHTT | |
| SCHEMBL7440999 | 0.89 | CASP1 (0.51) | TP53CASP1CASP3 | |
| SCHEMBL7677924 | 0.89 | CASP1 (0.55) | CASP1CASP3 | |
| SCHEMBL7443993 | 0.88 | MEN1 (0.46) | TP53CASP1ALDH1A1LMNACASP3 | |
| SCHEMBL7434358 | 0.87 | CASP1 (0.50) | TP53CASP1CASP3 | |
| SCHEMBL7436111 | 0.87 | CASP1 (0.49) | TP53CASP1CASP3 | |
| SCHEMBL7432733 | 0.87 | CASP1 (0.48) | TP53CASP1ALDH1A1CASP3PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | claimed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | claimed |
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |