Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 15/20 | 0.44 |
| ▸ | PLG | P00747 | 3/20 | 0.44 |
| ▸ | F12 | P00748 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | PLAT | P00750 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7446455 | 0.72 | PLAU (0.61) | PLAUPLGPRSS1F2PLAT | |
| SCHEMBL7343086 | 0.71 | PLAU (0.42) | PLAUPLGF12PRSS1PRSS2 | |
| SCHEMBL7335963 | 0.71 | PLAU (0.50) | PLAUPLGF12PRSS1F2 | |
| SCHEMBL7335251 | 0.69 | PLAU (0.42) | PLAUPLGPRSS1F2PLAT | |
| Trifluoroacetic Acid SCHEMBL7343080 | 0.69 | PLAU (0.57) | PLAUPLGF12PRSS1F2 | |
| SCHEMBL7345497 | 0.67 | PLAU (0.45) | PLAUPLGPRSS1F2PLAT | |
| Trifluoroacetic Acid SCHEMBL7336439 | 0.67 | PLAU (0.45) | PLAUPRSS1PRSS2PRSS3F2 | |
| SCHEMBL7334796 | 0.66 | PLAU (0.54) | PLAUPLGPRSS1F2PLAT | |
| SCHEMBL7341502 | 0.66 | PLAU (0.58) | PLAUPLGPRSS1F2PLAT | |
| SCHEMBL7334927 | 0.66 | PLAU (0.54) | PLAUPLGPRSS1F2PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000018-A2 | UROKINASE INHIBITORS | Abbott Laboratories (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005096-A2 | UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1999-02-04 | — | — | WO | disclosed |