Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442242 | 0.89 | LTA4H (0.69) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7416556 | 0.84 | LTA4H (0.61) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7353997 | 0.84 | LTA4H (0.61) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL6964901 | 0.84 | LTA4H (0.61) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7348199 | 0.84 | ESR1 (0.65) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7349591 | 0.84 | LTA4H (0.70) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7444253 | 0.84 | LTA4H (0.61) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7820185 | 0.83 | LTA4H (0.58) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7440099 | 0.83 | HRH3 (0.59) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7350306 | 0.82 | LTA4H (0.57) | LTA4HHRH3PSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863755-A4 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0863755-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997025033-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |