Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16391263 | 0.92 | KMT2A (0.47) | KMT2ALMNAMEN1ALDH1A1CYP2C9 | |
| SCHEMBL12592080 | 0.78 | AKR1C1 (0.46) | KMT2ALMNAMEN1AKR1C1CHRM2 | |
| SCHEMBL10233338 | 0.77 | KMT2A (0.43) | KMT2ALMNAMEN1ALDH1A1CYP2C9 | |
| SCHEMBL12592077 | 0.75 | AKR1C1 (0.47) | LMNAAKR1C1CHRM2CHRM1CHRM3 | |
| SCHEMBL10408648 | 0.75 | AKR1C1 (0.43) | KMT2ALMNAAKR1C1CHRM2CHRM1 | |
| SCHEMBL9486483 | 0.75 | AKR1C1 (0.43) | KMT2AMEN1AKR1C1CYP2D6NPSR1 | |
| SCHEMBL10599613 | 0.73 | CHRM1 (0.40) | KMT2ALMNAALDH1A1AKR1C1CHRM1 | |
| SCHEMBL12592073 | 0.72 | AKR1C1 (0.42) | LMNAAKR1C1CYP2D6NPSR1 | |
| SCHEMBL14861334 | 0.70 | CYP2C19 (0.33) | KMT2AMEN1KDM4ECYP2C19NPSR1 | |
| SCHEMBL517632 | 0.69 | ALOX5 (0.41) | KMT2ALMNAALDH1A1AKR1C1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005446-A1 | N-AROYLPHENYLALANINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999010313-A1 | N-AROYLPHENYLALANINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-03-04 | — | — | WO | disclosed |