Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443932 | 0.90 | KMT2A (0.51) | GSK3BKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7442480 | 0.88 | CDK2 (0.47) | GSK3BKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7445780 | 0.87 | KMT2A (0.45) | GSK3BKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7445281 | 0.86 | CDK2 (0.46) | GSK3BKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7442658 | 0.86 | GSK3B (0.56) | GSK3BKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7435005 | 0.85 | AGTR1 (0.44) | GSK3BKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7440327 | 0.85 | AGTR1 (0.39) | GSK3BAGTR1AGTR2KCNN3 | |
| SCHEMBL7433811 | 0.85 | GSK3B (0.42) | GSK3BKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7427188 | 0.84 | CDK2 (0.49) | GSK3BKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7440096 | 0.84 | AGTR1 (0.44) | GSK3BKMT2ANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |