Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 9/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10855771 | 0.81 | EPAS1 (0.56) | EPAS1EPHX2MAPTKDM4EALDH1A1 | |
| SCHEMBL10504446 | 0.75 | EPAS1 (0.61) | EPAS1EPHX2MAPTKDM4EALDH1A1 | |
| SCHEMBL11443229 | 0.75 | EPAS1 (0.61) | EPAS1EPHX2MAPTKDM4EALDH1A1 | |
| SCHEMBL13202776 | 0.73 | EPAS1 (0.59) | EPAS1EPHX2MAPTKDM4EALDH1A1 | |
| SCHEMBL7975860 | 0.73 | EPAS1 (0.54) | EPAS1EPHX2MAPTKDM4EALDH1A1 | |
| SCHEMBL29791659 | 0.72 | EPAS1 (1.00) | EPAS1EPHX2MAPTKDM4EALDH1A1 | |
| SCHEMBL9361501 | 0.72 | EPAS1 (1.00) | EPAS1EPHX2MAPTKDM4EALDH1A1 | |
| SCHEMBL18726163 | 0.71 | EPAS1 (0.53) | EPAS1EPHX2MAPTKDM4EALDH1A1 | |
| SCHEMBL14484081 | 0.71 | EPAS1 (0.53) | EPAS1EPHX2MAPTKDM4EALDH1A1 | |
| SCHEMBL223777 | 0.71 | MAPT (0.50) | EPAS1EPHX2MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |