Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447300 | 0.80 | CYP1A2 (0.41) | SMN1; SMN2CYP1A2POLBALDH1A1HTT | |
| SCHEMBL189495 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP1A2POLBALDH1A1HTT | |
| SCHEMBL7446084 | 0.78 | NOTUM (0.68) | SMN1; SMN2CYP1A2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL7440328 | 0.77 | ABCB1 (0.38) | SMN1; SMN2CYP1A2ALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL7445767 | 0.76 | ABCB1 (0.38) | SMN1; SMN2CYP1A2POLBALDH1A1L3MBTL1 | |
| SCHEMBL2840781 | 0.72 | HDAC6 (0.47) | SMN1; SMN2CYP1A2POLBALDH1A1HTT | |
| SCHEMBL31686338 | 0.71 | NOTUM (0.58) | SMN1; SMN2CYP1A2POLBALDH1A1HTT | |
| SCHEMBL7431655 | 0.71 | S1PR4 (0.38) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL2839518 | 0.71 | HDAC6 (0.47) | SMN1; SMN2CYP1A2POLBALDH1A1HTT | |
| SCHEMBL4019637 | 0.70 | IDO1 (0.55) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397364-B1 | HETEROCYCLIC GUANIDINES AS 5HT 3 ANTAGONISTS | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0397364-A1 | Heterocyclic guanidines AS 5HT 3 Antagonists | PFIZER INC. (US) | 1990-11-14 | — | — | EP | disclosed |
| US-4963689-A | ANTIEMETICS, ANALGESICS, GASTROINTESTINAL DISORDERS, SCHIZOPHRENIA | PFIZER INC. (US) | 1990-10-16 | — | — | US | disclosed |