Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364148 | 0.91 | CA1 (0.39) | CA1CA2TSHRCA12CA7 | |
| SCHEMBL3290589 | 0.79 | TSHR (0.41) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL8987497 | 0.79 | ADRB2 (0.39) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL10780556 | 0.77 | CYP3A4 (0.39) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL30940577 | 0.77 | ADRB2 (0.38) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL11003484 | 0.75 | TSHR (0.42) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL126725 | 0.75 | ADRB2 (0.36) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL30940559 | 0.75 | ADRB2 (0.36) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL25919320 | 0.75 | ADRB2 (0.42) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL13825811 | 0.75 | ADRB2 (0.36) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957915-A1 | AGENT FOR INHIBITION OF CYTOKINE PRODUCTION AND AGENT FOR INHIBITION OF CELL ADHESION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998014191-A1 | AGENT FOR INHIBITION OF CYTOKINE PRODUCTION AND AGENT FOR INHIBITION OF CELL ADHESION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-04-09 | — | — | WO | disclosed |
| US-4532239-A | N-phenoxypropanol-N'-pyridazinyl ethylendiamines as β-receptor blockers | CASSELLA AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |
| EP-0054946-B1 | BASIC SUBSTITUTED PYRIDAZINES, THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1984-08-15 | — | — | EP | disclosed |
| EP-0054946-A1 | Basic substituted pyridazines, their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1982-06-30 | — | — | EP | disclosed |
| US-4216314-A | CARDIOSELECTIVE B-ADRENOLYTIC AGENTS, ANTIARRHYTHMIC AGENTS AND HYPOTENSIVE AGENTS | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DE) | 1980-08-05 | — | — | US | disclosed |