Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16056887 | 0.88 | MEN1 (0.50) | MEN1BLMKMT2AADAM10ERBB2 | |
| SCHEMBL851578 | 0.88 | MEN1 (0.50) | MEN1BLMKMT2AADAM10ERBB2 | |
| SCHEMBL4074609 | 0.88 | MEN1 (0.50) | MEN1BLMKMT2AADAM10ERBB2 | |
| SCHEMBL4780406 | 0.88 | SLC1A2 (0.47) | MEN1BLMKMT2ASLC1A2 | |
| SCHEMBL199462 | 0.88 | SLC1A2 (0.47) | MEN1BLMKMT2ASLC1A2 | |
| SCHEMBL5203561 | 0.88 | SLC1A2 (0.47) | MEN1BLMKMT2ASLC1A2 | |
| SCHEMBL199463 | 0.88 | SLC1A2 (0.47) | MEN1BLMKMT2ASLC1A2 | |
| SCHEMBL199461 | 0.88 | SLC1A2 (0.47) | MEN1BLMKMT2ASLC1A2 | |
| SCHEMBL350996 | 0.88 | SLC1A2 (0.47) | MEN1BLMKMT2ASLC1A2 | |
| Hydrochloric Acid SCHEMBL2297675 | 0.86 | SLC1A2 (0.46) | MEN1BLMKMT2ASLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001971-A1 | DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006432-A1 | DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 1999-02-11 | — | — | WO | disclosed |