SCHEMBL7448165

SCHEMBL7448165

CC(=O)Nc1cccc(S(=O)(=O)Nc2ccc(-c3ccccc3)n(CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c2=O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ELANE P08246 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7440134 0.88 ELANE (0.86) ELANE
SCHEMBL9011645 0.87 ELANE (0.89) ELANE
SCHEMBL7439568 0.85 ELANE (0.81) ELANE
SCHEMBL7443449 0.85 ELANE (0.86) ELANE
SCHEMBL7436613 0.85 ELANE (0.89) ELANE
SCHEMBL7445407 0.85 ELANE (0.89) ELANE
SCHEMBL7500635 0.85 ELANE (0.85) ELANE
SCHEMBL9011925 0.84 ELANE (0.94) ELANE
SCHEMBL5076881 0.83 ELANE (1.00) ELANE
SCHEMBL9011872 0.83 ELANE (0.84) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5521179-A Heterocyclic amides ZENECA LIMITED (GB) 1996-05-28 US disclosed
WO-1993021212-A1 LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY ZENECA LIMITED (GB) 1993-10-28 WO disclosed