Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436433 | 0.90 | MEN1 (0.67) | MEN1KMT2AALOX15KDM4EMAPT | |
| SCHEMBL7440983 | 0.82 | TNF (0.61) | MEN1KMT2ATNF | |
| SCHEMBL7433768 | 0.80 | MEN1 (0.65) | MEN1KMT2AMAPTTNFTP53 | |
| SCHEMBL7434580 | 0.79 | MEN1 (0.74) | MEN1KMT2AMAPTTNFTP53 | |
| SCHEMBL7435468 | 0.77 | MEN1 (0.55) | MEN1KMT2AALOX15KDM4EMAPT | |
| SCHEMBL6285246 | 0.72 | TP53 (0.57) | MEN1KMT2AMAPTTNFTP53 | |
| SCHEMBL4857900 | 0.72 | TP53 (0.57) | MEN1KMT2AMAPTTNFTP53 | |
| SCHEMBL6288909 | 0.72 | TP53 (0.57) | MEN1KMT2AMAPTTNFTP53 | |
| SCHEMBL7446266 | 0.70 | TNF (0.65) | MEN1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7431322 | 0.70 | MEN1 (0.65) | MEN1KMT2AMAPTTNFTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703098-A | INHIBITORS OF CYTOKINES INCLUDING TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-30 | — | — | US | claimed |
| EP-0797437-B1 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNFalpha | CELGENE CORP (US) | 2001-04-18 | — | — | EP | disclosed |