Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 20/20 | 0.94 |
| ▸ | TPSD1 | Q9BZJ3 | 18/20 | 0.94 |
| ▸ | TPSG1 | Q9NRR2 | 18/20 | 0.94 |
| ▸ | PRSS1 | P07477 | 12/20 | 0.94 |
| ▸ | PRSS2 | P07478 | 10/20 | 0.94 |
| ▸ | PRSS3 | P35030 | 10/20 | 0.94 |
| ▸ | F2 | P00734 | 8/20 | 0.94 |
| ▸ | PLG | P00747 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551894 | 0.89 | TPSAB1 (0.94) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7447628 | 0.88 | TPSAB1 (0.94) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7599359 | 0.86 | TPSAB1 (0.78) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7419625 | 0.83 | TPSAB1 (1.00) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7447251 | 0.81 | TPSAB1 (0.73) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7446613 | 0.79 | TPSAB1 (0.94) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7447144 | 0.79 | TPSAB1 (0.77) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7447658 | 0.77 | TPSAB1 (0.76) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL7444123 | 0.76 | TPSAB1 (0.72) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7425638 | 0.76 | TPSAB1 (1.00) | TPSAB1TPSD1TPSG1PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |