Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 10/20 | 0.61 |
| ▸ | TP53 | P04637 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5100669 | 0.84 | ENPP2 (0.48) | ENPP2TP53MAPTLMNACYP3A4 | |
| SCHEMBL5110690 | 0.72 | ENPP2 (0.39) | ENPP2TP53MAPTTHRBLMNA | |
| SCHEMBL17966852 | 0.71 | ENPP2 (0.82) | ENPP2TP53MAPTTHRBLMNA | |
| SCHEMBL17966823 | 0.71 | ENPP2 (0.81) | ENPP2TP53MAPTTHRBLMNA | |
| SCHEMBL30100200 | 0.71 | ENPP2 (0.81) | ENPP2TP53MAPTTHRBLMNA | |
| SCHEMBL30100247 | 0.71 | ENPP2 (0.82) | ENPP2TP53MAPTTHRBLMNA | |
| SCHEMBL5100667 | 0.71 | TP53 (0.43) | ENPP2TP53MAPTTHRBCYP3A4 | |
| SCHEMBL15244309 | 0.69 | ENPP2 (0.77) | ENPP2TP53MAPTLMNA | |
| SCHEMBL17966952 | 0.68 | ENPP2 (0.94) | ENPP2TP53MAPTTHRBLMNA | |
| SCHEMBL19771429 | 0.68 | ENPP2 (1.00) | ENPP2TP53MAPTTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |