Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 13/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.47 |
| ▸ | ITGAV | P06756 | 7/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.47 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.40 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423011 | 0.87 | ITGB1 (0.52) | ITGB1ITGA5ITGAVITGA4ITGB7 | |
| SCHEMBL7445463 | 0.86 | ITGB1 (0.48) | ITGB1ITGA5ITGAVITGA4ITGB7 | |
| SCHEMBL7315770 | 0.85 | ITGA4 (0.59) | ITGB1ITGA5ITGAVITGA4ITGB7 | |
| SCHEMBL7073204 | 0.84 | ITGB1 (0.60) | ITGB1ITGA5ITGAVITGA4ITGB7 | |
| SCHEMBL7326216 | 0.83 | ITGB1 (0.49) | ITGB1ITGA5ITGAVITGA4ITGB7 | |
| SCHEMBL7324679 | 0.83 | ITGB1 (0.51) | ITGB1ITGA5ITGAVITGA4ITGB7 | |
| SCHEMBL7319192 | 0.83 | ITGB1 (0.48) | ITGB1ITGA5ITGAVITGA4ITGB7 | |
| SCHEMBL7325939 | 0.83 | ITGB1 (0.48) | ITGB1ITGA5ITGAVITGA4ITGB7 | |
| SCHEMBL7315537 | 0.82 | ITGB1 (0.50) | ITGB1ITGA5ITGAVITGA4ITGB7 | |
| SCHEMBL7318950 | 0.81 | ITGB1 (0.46) | ITGB1ITGA5ITGAVITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001972-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006431-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 1999-02-11 | — | — | WO | claimed |