Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5402643 | 0.83 | MAOB (0.34) | MEN1LMNAMAPTHTTKMT2A | |
| SCHEMBL5407585 | 0.83 | PDE4B (0.31) | MEN1LMNAMAPTHTTKMT2A | |
| SCHEMBL7448622 | 0.70 | MAP3K14 (0.42) | MEN1LMNAMAPTHTTKMT2A | |
| SCHEMBL12316702 | 0.69 | LMNA (0.37) | MEN1LMNAMAPTKMT2A | |
| SCHEMBL5477746 | 0.67 | MAP3K14 (0.35) | — | |
| SCHEMBL5402110 | 0.67 | MAP3K14 (0.35) | — | |
| SCHEMBL5399566 | 0.66 | MEN1 (0.36) | MEN1LMNAMAPTHTTKMT2A | |
| SCHEMBL5399565 | 0.65 | — | — | |
| SCHEMBL6606462 | 0.64 | — | — | |
| SCHEMBL5410275 | 0.63 | MAOB (0.34) | MEN1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140820-A1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035869-A1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | ASTRAZENECA AB (SE) | 2000-06-22 | — | — | WO | disclosed |