Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.83 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.83 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.38 |
| ▸ | FPR2 | P25090 | 4/20 | 0.37 |
| ▸ | FPR1 | P21462 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449106 | 0.93 | ITGB3 (0.72) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7446820 | 0.93 | ITGB3 (0.80) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7455144 | 0.93 | ITGB3 (0.80) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7455508 | 0.92 | ITGB3 (0.70) | ITGB3ITGA2BFPR2FPR1HDAC1 | |
| SCHEMBL7450550 | 0.92 | ITGB3 (0.70) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| Orbofiban SCHEMBL7854981 | 0.91 | ITGB3 (1.00) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| Orbofiban SCHEMBL7415135 | 0.91 | ITGB3 (1.00) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7450175 | 0.91 | ITGB3 (0.69) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7454357 | 0.91 | ITGB3 (0.69) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7445983 | 0.91 | ITGB3 (0.77) | ITGB3ITGA2BPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025358-A | Double prodrugs of potent GP IIb/IIIa antagonists | G. D. SEARLE & CO. (US) | 2000-02-15 | — | — | US | claimed |
| WO-1999064397-A1 | DOUBLE PRODRUGS OF POTENT GPIIb/IIIa ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-12-16 | — | — | WO | claimed |
| US-6025358-A | Double prodrugs of potent GP IIb/IIIa antagonists | G. D. SEARLE & CO. (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1999064397-A1 | DOUBLE PRODRUGS OF POTENT GPIIb/IIIa ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-12-16 | — | — | WO | disclosed |