Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449037 | 1.00 | HPGD (0.48) | HPGDSIRT5FFAR1FFAR4SERPINE1 | |
| SCHEMBL7449053 | 1.00 | HPGD (0.48) | HPGDSIRT5FFAR1FFAR4SERPINE1 | |
| SCHEMBL8724013 | 0.97 | HPGD (0.48) | HPGDSIRT5FFAR1FFAR4SERPINE1 | |
| SCHEMBL8724010 | 0.97 | HPGD (0.48) | HPGDSIRT5FFAR1FFAR4SERPINE1 | |
| SCHEMBL8724019 | 0.97 | HPGD (0.48) | HPGDSIRT5FFAR1FFAR4SERPINE1 | |
| SCHEMBL7446615 | 0.96 | HPGD (0.47) | HPGDSIRT5FFAR1FFAR4SERPINE1 | |
| SCHEMBL7446627 | 0.96 | HPGD (0.47) | HPGDSIRT5FFAR1FFAR4SERPINE1 | |
| SCHEMBL7434102 | 0.90 | HPGD (0.46) | HPGDSIRT5MEN1KMT2ABACE1 | |
| SCHEMBL7434093 | 0.90 | HPGD (0.46) | HPGDSIRT5MEN1KMT2ABACE1 | |
| SCHEMBL27432152 | 0.88 | HPGD (0.45) | HPGDSIRT5FFAR1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707586-B1 | POSITIVE INOTROPIC AND LUSITROPIC PYRROLOQUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1998-09-16 | — | — | EP | disclosed |
| US-5602134-A | USEFUL FOR TREATING ANIMALS SUFFERING FROM CONGESTIVE HEART FAILURE | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-02-11 | — | — | US | disclosed |
| EP-0707586-A1 | POSITIVE INOTROPIC AND LUSITROPIC PYRROLOQUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995000512-A1 | POSITIVE INOTROPIC AND LUSITROPIC PYRROLOQUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-01-05 | — | — | WO | disclosed |