Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434093 | 1.00 | HPGD (0.46) | HPGDGPR35SIRT5PPARGHDAC4 | |
| SCHEMBL7449041 | 0.90 | HPGD (0.48) | HPGDSIRT5BACE1MEN1KMT2A | |
| SCHEMBL7449037 | 0.90 | HPGD (0.48) | HPGDSIRT5BACE1MEN1KMT2A | |
| SCHEMBL7449053 | 0.90 | HPGD (0.48) | HPGDSIRT5BACE1MEN1KMT2A | |
| SCHEMBL8724013 | 0.89 | HPGD (0.48) | HPGDSIRT5SMN1; SMN2 | |
| SCHEMBL8724010 | 0.89 | HPGD (0.48) | HPGDSIRT5SMN1; SMN2 | |
| SCHEMBL8724019 | 0.89 | HPGD (0.48) | HPGDSIRT5SMN1; SMN2 | |
| SCHEMBL7446627 | 0.88 | HPGD (0.47) | HPGDSIRT5PPARGSMN1; SMN2 | |
| SCHEMBL7446615 | 0.88 | HPGD (0.47) | HPGDSIRT5PPARGSMN1; SMN2 | |
| SCHEMBL27523082 | 0.87 | ALDH1A1 (0.47) | HPGDNPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707586-B1 | POSITIVE INOTROPIC AND LUSITROPIC PYRROLOQUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1998-09-16 | — | — | EP | disclosed |
| US-5602134-A | USEFUL FOR TREATING ANIMALS SUFFERING FROM CONGESTIVE HEART FAILURE | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-02-11 | — | — | US | disclosed |
| EP-0707586-A1 | POSITIVE INOTROPIC AND LUSITROPIC PYRROLOQUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995000512-A1 | POSITIVE INOTROPIC AND LUSITROPIC PYRROLOQUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-01-05 | — | — | WO | disclosed |