Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 7/20 | 0.58 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.52 |
| ▸ | ITGAV | P06756 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CMA1 | P23946 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321647 | 0.96 | ITGB1 (0.62) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL7315498 | 0.96 | ITGB1 (0.58) | ITGB1ITGA5ITGA4ITGAVKMT2A | |
| SCHEMBL7316198 | 0.96 | ITGB1 (0.58) | ITGB1ITGA5ITGA4ITGAVKMT2A | |
| SCHEMBL7317563 | 0.86 | ITGB1 (0.63) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL5691000 | 0.82 | ITGB1 (0.59) | ITGB1ITGA5ITGA4ITGAVKMT2A | |
| SCHEMBL5690998 | 0.82 | ITGB1 (0.59) | ITGB1ITGA5ITGA4ITGAVKMT2A | |
| SCHEMBL5690742 | 0.82 | ITGB1 (0.71) | ITGB1ITGA5ITGA4ITGAVKMT2A | |
| SCHEMBL7325049 | 0.82 | ITGB1 (0.63) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL7066469 | 0.82 | ALDH1A1 (0.70) | ITGB1ITGA5ITGA4ITGAVKMT2A | |
| SCHEMBL7069740 | 0.82 | ALDH1A1 (0.70) | ITGB1ITGA5ITGA4ITGAVKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001972-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006431-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 1999-02-11 | — | — | WO | claimed |