Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 7/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442407 | 0.89 | PTGER1 (0.43) | PTGER1TLR7PTGER4PTGER3PTGER2 | |
| SCHEMBL7453282 | 0.88 | PTGER1 (0.46) | PTGER1TLR7PTGER4PTGER3PTGER2 | |
| SCHEMBL7445698 | 0.86 | PTGER1 (0.45) | PTGER1TLR7PTGER4PTGER3PTGER2 | |
| SCHEMBL7444720 | 0.86 | PTGER1 (0.43) | PTGER1TLR7PTGER4PTGER3PTGER2 | |
| SCHEMBL7453775 | 0.83 | PTGER1 (0.48) | PTGER1TLR7 | |
| SCHEMBL7446264 | 0.81 | TLR7 (0.50) | PTGER1TLR7PTGER4PTGER3PTGER2 | |
| SCHEMBL7449277 | 0.81 | PTGER1 (0.47) | PTGER1TLR7PTGER4PTGER3PTGER2 | |
| SCHEMBL7443767 | 0.79 | PTGER1 (0.51) | PTGER1TLR7MAOBKDM4E | |
| SCHEMBL7449236 | 0.79 | PTGER1 (0.46) | PTGER1TLR7PTGER4PTGER3PTGER2 | |
| SCHEMBL7452183 | 0.79 | SMPD1 (0.54) | PTGER1TLR7MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | claimed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | claimed |
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |