Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9591405 | 0.84 | MEN1 (0.56) | CCR3MEN1KMT2AFAAH | |
| SCHEMBL5374680 | 0.80 | ACHE (0.56) | CCR3SLC6A2SLC6A4 | |
| SCHEMBL5373096 | 0.78 | GRIN2B (0.53) | MEN1KMT2A | |
| SCHEMBL28138491 | 0.78 | HTT (0.65) | HTTKMT2A | |
| SCHEMBL11389740 | 0.78 | TACR3 (0.57) | MEN1KMT2AFAAH | |
| SCHEMBL4986574 | 0.78 | CCR3 (0.51) | CCR3HTTMEN1KMT2AFAAH | |
| SCHEMBL7232379 | 0.77 | HTT (0.73) | HTTMEN1KMT2ARAB9A | |
| SCHEMBL2399935 | 0.76 | HTT (0.96) | HTTKMT2ARAB9A | |
| SCHEMBL6570865 | 0.75 | HTT (0.66) | HTTMEN1KMT2AFAAH | |
| SCHEMBL15007990 | 0.75 | CCR3 (0.51) | CCR3HTTMEN1KMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410540-B1 | HEART AND KIDNEY DISEASES; ANTIINFLAMMATORY AGENTS | SCIOS, INC. | 2002-06-25 | — | — | US | disclosed |
| WO-2001064676-A2 | INHIBITORS OF p38-α KINASE | SCIOS, INC. (US) | 2001-09-07 | — | — | WO | disclosed |
| EP-1107758-A2 | USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE | SCIOS INC. (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012074-A2 | USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE | SCIOS INC. (US) | 2000-03-09 | — | — | WO | disclosed |