Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 15/20 | 0.60 |
| ▸ | HTR1D | P28221 | 15/20 | 0.60 |
| ▸ | HTR1A | P08908 | 3/20 | 0.60 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450390 | 1.00 | HTR1B (0.60) | HTR1BHTR1DHTR1ADRD4DRD3 | |
| SCHEMBL7450379 | 1.00 | HTR1B (0.60) | HTR1BHTR1DHTR1ADRD4DRD3 | |
| SCHEMBL7448912 | 0.77 | HTR1D (0.84) | HTR1BHTR1DHTR1A | |
| SCHEMBL7439194 | 0.77 | HTR1D (0.84) | HTR1BHTR1DHTR1A | |
| SCHEMBL8312369 | 0.75 | HTR1D (1.00) | HTR1BHTR1DHTR1A | |
| SCHEMBL7435314 | 0.75 | DRD2 (0.56) | HTR1BHTR1DHTR1ADRD4DRD3 | |
| SCHEMBL7439927 | 0.75 | DRD2 (0.56) | HTR1BHTR1DHTR1ADRD4DRD3 | |
| SCHEMBL7439930 | 0.75 | DRD2 (0.56) | HTR1BHTR1DHTR1ADRD4DRD3 | |
| SCHEMBL8312983 | 0.71 | HTR1B (1.00) | HTR1BHTR1DHTR1A | |
| SCHEMBL8316699 | 0.71 | HTR1D (1.00) | HTR1BHTR1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |