Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16804172 | 0.71 | MAPT (0.70) | MAPTNPC1HTTRAB9AESR1 | |
| SCHEMBL25044208 | 0.70 | MAPT (0.66) | MAPTNPC1HTTRAB9AESR1 | |
| SCHEMBL13683411 | 0.69 | MAPT (0.34) | MAPTNPC1HTTRAB9AKDM4E | |
| SCHEMBL16781493 | 0.68 | ESR1 (0.56) | MAPTNPC1HTTRAB9AESR1 | |
| SCHEMBL16804171 | 0.68 | MAPT (0.62) | MAPTNPC1HTTRAB9AESR1 | |
| SCHEMBL7449824 | 0.68 | AURKA (0.36) | — | |
| SCHEMBL21061389 | 0.67 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL16781495 | 0.65 | ESR1 (0.52) | MAPTNPC1HTTRAB9AESR1 | |
| SCHEMBL11448549 | 0.65 | AURKA (0.39) | HTT | |
| SCHEMBL18470709 | 0.64 | ESR1 (0.55) | MAPTNPC1HTTRAB9AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |